Endo-microscopic optical coherence tomography (emOCT) with dynamic contrast

  • Schulz-Hildebrandt H
  • Ahrens M
  • Münter M
  • et al.
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Abstract

Here we present a forward-looking endoscope for dynamic microscopic OCT reaching a lateral resolution of 1.3 µm and 0.8 mm field of view. Since tissue motion degrades dynamic imaging, tissue was immobilized by suction. The endoscope was placed in a 4 mm stainless-steel sheath, which was connected to a vacuum pump. In mice, the endoscope can access various inner organs using open surgery or laparoscopy. The potential of the dynamic endo-microscopic OCT was demonstrated on relevant murine tissue such as liver, spleen and kidney. Otherwise invisible cellular and subcellular structures were imaged by dynamic mOCT with high contrast.

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Schulz-Hildebrandt, H., Ahrens, M., Münter, M., Wilken, E., Kohlfärber, T., Holzhausen, C., … Hüttmann, G. (2021). Endo-microscopic optical coherence tomography (emOCT) with dynamic contrast (p. 10). SPIE-Intl Soc Optical Eng. https://doi.org/10.1117/12.2575733

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