Abstract
Comparative antimicrobial activity studies for certain new classes of soft N‐chloramines derived from α‐aminoisobutyric acid and 2‐amino‐2‐methyl‐1‐propanol were examined using the minimum inhibitory concentration (MIC) and/or the contact germicidal efficiency (CGE) procedures. Several factors significantly influence the antimicrobial activity of the soft N‐chloramines: (a) the aliphatic chain length in a homologous series, (b) the degree of chlorination of the nitrogen atom, (c) the solution pH, (d) the presence of a denaturant, and (e) the nature of a positive charge. Copyright © 1976 Wiley‐Liss, Inc., A Wiley Company
Author supplied keywords
- Antimicrobial activity—N‐chloramine derivatives of α‐aminoisobutyric acid and 2‐amino‐2‐methyl‐1‐propanol evaluated
- N‐Chloramines, soft—series with low chlorine potential, antimicrobial activity evaluated and compared
- N‐Halo derivatives—low chlorine potential, soft N‐chloramines, antimicrobial activity evaluated and compared
- Structure‐activity relationships—N‐chloramine derivatives of α‐aminoisobutyric acid and 2‐amino‐2‐methyl‐1‐propanol evaluated for antimicrobial activity
Cite
CITATION STYLE
Kaminski, J. J., Maureen Huycke, M., Selk, S. H., Bodor, N., & Higuchi, T. (1976). N‐halo derivatives V: Comparative antimicrobial activity of soft N‐chloramine systems. Journal of Pharmaceutical Sciences, 65(12), 1737–1742. https://doi.org/10.1002/jps.2600651211
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