Matrix metalloproteinases

Abstract

Matrix-degrading enzymes, matrix metalloproteinases, are members of a unique family of Zinc-binding endopeptidases that are responsible for the metabolism of extracellular components in the tissue stroma. Their controlled expression is essential for normal processes such as wound healing and tissue remodeling, including embryogenesis. However, in many pathological conditions and events such as metastasis of malignant tumors and rheumatoid arthritis, the uncontrolled expression is evident.