Green Synthesis, Antimicrobial Activity and Cytotoxicity of Novel Fused Pyrimidine Derivatives Possessing a Trifluoromethyl Moiety

Abstract

A series of novel fused pyrimidine derivatives possessing a trifluoromethyl moiety have been synthesized by the reaction of the enaminone named E-3-(dimethylamino)1-(4-(trifluoromethyl)phenyl)prop-2-en-1-one with a variety of heterocyclic amines under solvent free mechanochemical condition utilizing nano sized magnesium oxide catalyst. 1H–15N HMBC (Heteronuclear Multiple Bond Correlation) NMR technique was used to allow for the unambiguous structural characterization of the fused pyrimidine products. The newly synthesized fused pyrimidines were investigated for their antimicrobial and anticancer activity. A pronounced inhibitory effect on the growth of the tested cell lines was recorded by the examined newly synthesized fused pyrimidines.