Use of circular dichroism to determine the absolute configuration of a pimarane diterpenoid from the southern african sclerocroton integerrimus (Euphorbiaceae)

Abstract

From the stem bark and leaves of Sclerocroton integerrimus, eight compounds, including 17-hydroxy-ent-pimara-8(14),15-dien-3-one (1), were isolated. The structures of the compounds were determined on the basis of spectroscopic analysis. The absolute configuration of 17-hydroxy-ent-pimara- 8(14),15-dien-3-one was confirmed from electronic circular dichroism studies.