Journal ArticleOPEN ACCESS

The role of acetylation in the subcellular localization of an oncogenic isoform of translation factor eIF5A

Bioscience, Biotechnology and Biochemistry (2012) 76(11) 2165-2167
DOI: 10.1271/bbb.120620
21Citations
Citations of this article
35Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Mammalian cells express two isoforms of eIF5A, eIF5A1 and eIF5A2, but little is known about the function of eIF5A2. Here we report that eIF5A2 is reversibly acetylated at lysine-47. HDAC6 and SIRT2 were identified as the enzymes responsible for deacetylating eIF5A2. Analysis using acetylation-deficient mutants indicated that acetylation regulates the subcellular localization of eIF5A2.

Author supplied keywords

Cite

CITATION STYLE

APA

Ishfaq, M., Maeta, K., Maeda, S., Natsume, T., Ito, A., & Yoshida, M. (2012). The role of acetylation in the subcellular localization of an oncogenic isoform of translation factor eIF5A. Bioscience, Biotechnology and Biochemistry, 76(11), 2165–2167. https://doi.org/10.1271/bbb.120620

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free