Avaliação do nível da vulnerabilidade do solo devido à presença de termelétrica a carvão (Figueira, PR- Brasil)

Abstract

SCREENING FOR ACETYLCHOLINESTERASE INHIBITORS FROM PLANTS TO TREAT ALZHEIMERS DISEASE. Alzheimers disease (AD) is a neurodegenerative disease characterized by cognite impairment and personality changes. The development of drugs for the treatment of the cognitive deficits of AD has focused on agents which counteract loss in cholinergic activities. These symptons of AD have been successfully treated with acetylcholinesterase (AchE) inhibitors (eg. galanthamine). There still is great interest in finding better AchE inhibitors. We use Ellmanns microplate assay and silica gel thin-layer chromatography (TLC) to screen natural products from plants as new sources of AchE inhibitors.