Indole alkaloids in human medicine

Abstract

Total synthesis of several pharmacologically active indole alkaloids isolated from Vinca minor and Catharanthus roseus present a real challenge. Several aspects of synthesis of these alkaloids are discussed and a new skeletal rearrangement of the 1, 2-dehydro-ψ -aspidospermane into a ψ-eburnane--type skeleton is presented. © 1990 IUPAC