Pharmacological Activity of Mangrove Plant Bioactive Compounds Against Cancer Cell Changes: A Systematic Review

Abstract

Cancer is a condition when the body's cells begin to grow abnormally and uncontrollably. Cancer therapy which is often used in medicine is non-selective, it can affect other normal cells that have a toxic effect in addition beside the activity as anticancer, to overcome this herbal plants have potential as anti-cancer one of them is mangroves. The research method uses a systematic review of the Science Direct, Pubmed, and Google Scholar databases that meet the inclusion and exclusion criteria. The results of the analysis show that the cytotoxic potential of cancer cells can be done by calculating the percentage of living cells with an IC50 value, which is a concentration that can kill half of cancer cells. The content of bioactive compounds from mangrove plant extracts include taurine, apigenin, lupeol, quercetin, alkaline benzoquinone, polyprenol and dolichol which have antioxidant and anticancer activity. These compounds work as mitogenic agents, namely inflammatory activation, cell mobility, angiogenesis, inhibition of protein kinases, antiproliferation, induction of apoptosis, and inhibition of metastasis.