Asymmetric michael reaction of aldehyde and β-substituted α-nitroacrylate catalyzed by diphenylprolinol silyl ether

Abstract

The asymmetric Michael reaction of an aldehyde and β-substituted α-nitroacrylate, catalyzed by diphenylprolinol silyl ether, was successfully carried out and good yield was achieved. This reaction has broad substrate generality. Moreover, the product can be easily converted to pyrrolidine or lactone.