Synthesis and antibacterial activity of new antibiotics arising from cephalosporin-monobactam coupling

Abstract

New β-lactam antibiotics were obtained by coupling the cephalosporin Cefotaxime with monobactams in order to assess the possibility to enhance the cephalosporin activity through a synergistic dual-action mechanism. The activities were tested, in vitro, against a panel of selected bacteria. Preliminary results showed a light change in antibacterial activity when compared with that of the starting cephem counterpart.