Gynandroblastoma of ovary with juvenile granulosa cell component and heterologous intestinal type glands

Abstract

An ovarian gynandroblastoma in a 15-year-old girl is described. The predominant component was juvenile granulosa cell tumour. Areas of adult granulosa cell tumour and Sertoli cell elements were also present. Stromal theca and luteinised cells were identified. An additional histological finding was the presence of heterologous intestinal type glands. There was positive immunohistochemical staining of juvenile and adult granulosa cell areas with inhibin and MIC2 antibodies. Electronmicroscopy showed a close ultrastructural resemblance between tumour cells in granulosa and Sertol cell areas, in spite of differences in architectural pattern, suggesting that both morphorogical components may derive from a single cell of origin. The tumour demonstrates a unique combination of elements which has not previously been described.