Lipid Nanoparticles for Ocular Drug Delivery

Abstract

Despite numerous scientific efforts, efficient ocular drug delivery remains a challenge for pharmaceutical scientists. Delivery of ophthalmic drugs to the targeted ocular tissues is limited by many precorneal, dynamic and static ocular barriers. The anatomy, physiology and biochemistry of the eye render this organ exquisitely impervious to foreign substances. One of the promising strategies nowadays is the use of colloidal carrier systems characterized by a submicron-meter size. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) represent promising alternatives to conventional and very popular ocular carrier systems.