Field evaluation of an orf vaccine in sheep and goat flocks with high neonatal mortality

Abstract

A high percent of annual neonatal mortality attributed to orf infection was observed between 2001 and 2004 in 2 sheep and 2 mixed (sheep and goat) flocks of Northern Greece. In order to protect the neonatal lambs and kids from orf infection a commercially available live orf vaccine was used. Pregnant sheep and goats were vaccinated subcutaneously a month before parturition, while 10 sheep and 10 goats in each flock remained unvaccinated and were used as negative controls. The vaccine was significantly effective (P<0.05) in reducing the orf lesions and the mortality rate in lambs and kids of the 4 flocks. During the next year 3 of the 4 flocks were revaccinated. A significantly low percentage of orf lesions and neonatal mortality continued to occur in revaccinated flocks, while a significant percentage (P<0.05) of orf lesions and neonatal mortality reappeared in the nonrevaccinated flock. The antibody titres in vaccinated sheep and goats were increased significantly on days 60 and 105 post-vaccination, while the titres in the controls remained low (P<0.05).Visok stepen godisnje smrtnosti neonatalnih zivotinja doprineo je orf infekcijama uocenim izmedju 2001 i 2004 kod dva stada ovaca i dva mesovita stada ovaca i koza u severnoj Grckoj. Komercijalno dostupna ziva orf vakcina je upotrebljena da bi se zastitila neonatalna jagnjad i jarad od orf infekcije. Bredje ovce i koze su vakcinisane subkutano mesec dana pre partusa, dok je 10 ovaca i 10 koza u svakom stadu ostalo nevakcinisano i posluz ile su kao negativne kontrole. Vakcina je bila znacajno efikasna (P<0,05) u smanjenju orf lezija i stope smrtnosti kod jagnjadi i jaradi sva cetiri stada. Tokom sledece godine, 3 od 4 stada su revakcinisana. Nastavljena je pojava znacajno niskog procenta orf lezija i smrtnosti neonatalnih zivotinja u revakcinisanim stadima, dok se ponovo pojavio znacajan procenat (P<0,05) orf lezija i smrtnosti neonatalnih zivotinja kod stada koja nisu revakcionisana. Titri antitela kod vakcinisanih ovaca i koza su bili znacajno poviseni 60 i 105 dana posle vakcinacije, dok su titri kod kontrola ostali niski (P<0,05).