Unusual Verrucous Skin Lesion in Diabetic Neuropathy Following Toe Amputation and Skin Grafting

Abstract

Verrucous skin lesions in diabetic neuropathy (VSLDN) are rare and typically occur at weight-bearing sites due to chronic mechanical stress. This case report describes a 35-year-old man with type 2 diabetes mellitus who developed a verrucous lesion on the dorsum of his left foot following toe amputation and skin grafting. Histological analysis identified pseudoepitheliomatous hyperplasia with no evidence of malignancy or human papillomavirus infection. The lesion gradually resolved with the application of maxacalcitol ointment and the use of elastic stockings. This case highlights the importance of recognizing atypical verrucous lesions in patients with diabetes, particularly at non-weight-bearing sites after surgical interventions. Accurate differentiation between plantar warts and verrucous carcinomas is essential for appropriate management. Effective treatment and comprehensive patient education on foot care are crucial for improving outcomes and preventing further complications in patients with diabetes.