Infectious mass debulking in lead-associated endocarditis with a percutaneous aspiration system

Abstract

Aims Debulking of infective mass to reduce the burden if infective material is a fundamental principle in the surgical management of infection. The aim of this study was to investigate the validity of this principle in patients undergoing transvenous lead extraction in the context of bloodstream infection (BSI) Methods We performed an observational single-centre study on patients that underwent transvenous lead extraction due to a BSI, and results with or without lead-associated vegetations, in combination with a percutaneous aspiration system during the study period 2015–22. One hundred thirty-seven patients were included in the final analysis. In patients with an active BSI at the time of intervention, the use of a percutaneous aspiration system had a significant impact on survival (log-rank: P = 0.0082), while for patients with a suppressed BSI at the time of intervention, the use of a percutaneous aspiration system had no significant impact on survival (log-rank: P = 0.25) Conclusion A reduction of the infective burden by percutaneous debulking of lead vegetations might improve survival in patients with an active BSI.