Recognition of non-self-polysaccharides by C-type lectin receptors dectin-1 and dectin-2

Abstract

The discovery of several transmembrane receptors expressed by antigen presenting cells, including those that detect and interact with specific sugar moieties on the surface of microbes, has improved our understanding of how immunity against infection is generated. This knowledge, in turn, prompted us to review such interactions with emphasis on C-type lectin receptors and a focus on the roles of dectin-1 and dectin-2 in anti-fungal immunity. © The Author 2009. Published by Oxford University Press. All rights reserved.