Meroterpenes from endophytic fungus A1 of mangrove plant Scyphiphora hydrophyllacea

Abstract

Four new meroterpenes, guignardones F-I (1-4), together with two known compounds guignardones A (5) and B (6 ) were isolated from the endophytic fungus A1 of the mangrove plant Scyphiphora hydrophyllacea. Their structures and relative configurations were elucidated by spectroscopic data and single-crystal X-ray crystallography. A possible biogenetic pathway of compounds 1-6 was also proposed. All compounds were evaluated for inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus. © 2012 by the authors; licensee MDPI.