Mesoporous-Silica-Functionalized Nanoparticles for Drug Delivery

Abstract

The ever-growing interest for finding efficient and reliable methods for treatment of diseases has set a precedent for the design and synthesis of new functional hybrid materials, namely porous nanoparticles, for controlled drug delivery. Mesoporous silica nanoparticles (MSNPs) represent one of the most promising nanocarriers for drug delivery as they possess interesting chemical and physical properties, thermal and mechanical stabilities, and are biocompatibile. In particular, their easily functionalizable surface allows a large number of property modifications further improving their efficiency in this field. This Concept article deals with the advances on the novel methods of functionalizing MSNPs, inside or outside the pores, as well as within the walls, to produce efficient and smart drug carriers for therapy. Responding well to silica: Mesoporous silica nanoparticles (MSN) represent one of the most promising nanocarriers for drug delivery (see figure). This concept article describes how their functionalization has allowed the design of more efficient systems by improving their specific retention and uptake with targeted and stimuli-responsive properties.