Successful Transporter Gets an EGO Boost

Abstract

The trafficking of nutrient transporters is highly regulated and controlled by a variety of signal transduction pathways. A recent study by Gao and Kaiser (2006) in Nature Cell Biology demonstrates a role for a novel GTPase-containing complex that allows the amino acid permease Gap1 to recycle out of late endosomal compartments. This complex is likely to play critical roles in allowing animal cells to mobilize their nutrient transporters in response to metabolic demands. © 2006 Elsevier Inc. All rights reserved.