Human omental adipose-derived stem cells from donors with different body mass index had similar effects on proliferation and migration of endometrial cancer cells in vitro

Abstract

Aim: This study aimed to confirm whether human omental adipose-derived stem cells (O-ASC) from donors with varying body mass index (BMI, calculated in kg/m2) exert different effects on proliferation and migration of endometrial cancer (EC) cells. Methods: Omental adipose-derived stem cells were isolated from the omental adipose tissues of eight patients who were diagnosed with EC aged from 35 to 56 years. According to the patients’ BMI, the O-ASC was divided into two groups: obesity group (BMI ≥ 30) and normal group (18.5 < 0.05) whereas without any effects on Hec-1A cells. Both horizontal and vertical migrations of EC cells were promoted by O-ASC (P < 0.01). However, there were no statistical differences between the two groups. Conclusion: Human O-ASC could influence the proliferation and migration of EC cells in vitro but the effects were not modified by donors’ BMI.