Four New Azaphilones from Chaetomium globosum var. flavo-viridae

Abstract

Four new azaphilones of angular type, named chaetoviridins A, B, C and D, were isolated from the culture of Chaetomium globosum var. flavo-viridae. The absolute configuration of chaetoviridin A was established on the basis of the spectral data and chemical reactions. The structures of chaetoviridins B, C and D were suggested by the spectral data. The result of a biosynthetic study of chaetoviridin B from sodium [l,2-13C2\acetate gave support to the angular structure. © 1990, The Pharmaceutical Society of Japan. All rights reserved.