Myasthenia Gravis and pregnancy

Abstract

Myasthenia Gravis is a chronic neuromuscular disease in women of childbearing age. Its course during pregnancy is unpredic-table, with higher exacerbation rates in the first trimester or in the postpartum period. In addition, the delivery phase in these pregnant women often requires greater medical intervention due to a greater risk of intrapartum complications. We present the case of a 27-year-old pregnant woman diagnosed with Myasthenia gravis, in which a joint follow-up was carried out by the High Risk Obstetric and Neurology Unit. The gestation had a favorable evolution, without presenting a period of exacerbations or requiring therapeutic modifications. The pregnancy ended at term, by means of instrumented delivery with forceps due to maternal fatigue, with a healthy newborn. Regarding the reported clinical case, a bibliographic review has been carried out in the PubMed, MedLine, Embase, BioMed Central and SciELO databases in search of the most up-to-date scientific evidence. It can be concluded that the clinical course of the disease is highly variable, with a non-negligible number of patients suffering a clinical worsening. Furthermore, the scarcity of published cases makes standardized management of the disease difficult, which today continues to pose a challenge for obstetricians and neurologists.