The Efficacy of Therapeutic-Diabetes Mellitus Functional Drink on Blood Glucose and Plasma Malondialdehyde (MDA) Levels of Type 2 Diabetes Mellitus Patients

Abstract

A long-time condition of hyperglycemia in type 2 diabetes mellitus (DM) will cause glucose auto-oxidation, which can increase reactive oxygen stress. Improving the balance between the composition of gut microbiota and host cells in DM patients with prebiotics and probiotics concepts is a therapy to reduce the risk of ongoing inflammation. This study aimed to examine the efficacy of the therapeutic diabetes mellitus functional beverage product from local functional food on blood glucose levels and plasma malondialdehyde (MDA) levels of type 2 DM patients. This study used a "pre-posttest control design". The research subjects were 46 patients with type 2 DM who were divided into two groups: the intervention and control groups. The research sample was selected by a purposive sampling technique. The intervention was conducted by giving 200 ml of yogurt bengkuang tape ketan hitam for two weeks. Meawhile, the statistical test used an independent t-test. The results showed that the samples did not have a difference in the mean blood glucose levels before and after the Yobetam treatment. The blood glucose levels of the control group were 4.9 ± 39.3, and those of the intervention group were -14.1 ± 52.1. However, the samples showed a difference in the mean MDA levels before and after the Yobetam treatment. The mean MDA levels of the control group were 0.16 ± 0.39, and those of the intervention group were 0.46 ± 0.37. The functional drink is expected to be an alternative to oral therapy.