Surveillance of moderate-size aneurysms of the thoracic aorta

Abstract

Background: There are no evidence based guidelines for the surveillance of patients with moderate-sized (<5 m) thoracic aortic aneurysms (MTAA), who do not warrant surgical intervention. The purpose of this study was to review the MTAA patient surveillance strategy used currently at the Northport Veterans Affairs Medical Center, to assess outcomes over time and accrue data to develop guidelines to optimize MTAA patients' follow-up. Methods: The study group included veterans referred to the Thoracic Surgery clinic for the management of moderate-sized (<5 cm) thoracic aortic aneurysms (MTAA) not warranting immediate surgical repair. Results: For 110 MTAA patients, the average presenting index size was 4.45±0.4 cm with average growth of 0.04 cm total (0.03 cm/year). Fourteen (13%) patients met the adverse composite endpoint, with no MTAA-related deaths. Patients achieving the adverse composite endpoint had higher index sizes (4.81 vs. 4.40 cm, p=0.001) and higher average growth rates as compared to non-endpoint patients (0.16 vs. 0.01 cm, p=0.0009). Optimizing the negative likelihood ratio defined a new "not-at-risk" population with aneurysm index size<4.3 cm. A shorter time to adverse event for "at-risk" patients was found versus "not-at-risk" patients (p=0.02). On average, there were 4.8 CT scans/patient and estimated cumulative radiation dose of 34 mSv/patient. Only one "not-at-risk" patient had substantive MTAA growth (≥0.5 cm/year) over the 8 year follow-up period. Conclusion and relevance: Annual imaging of MTAA "not-at-risk" patients appears unwarranted, resulting in potentially excessive radiation exposure. Although additional research is necessary for validation, longer surveillance imaging intervals (beyond one year) seem appropriate for MTAA patients presenting with<4.3 cm index aneurysms.