Xanthine Oxidase Inhibitory Activity of Xanthones from Calophyllum pseudomole P. F. Stevens

Abstract

The genus Calophyllum (Calophyllaceae) is a plant proven to produce various xanthones, chromanoic acids, and 4-phenyl coumarins. This study aims to determine the xanthine oxidase inhibitory activity of xanthones from Calophylum pseudomole P.F. Stevens. Two xanthones, ananixanthone (1) and caloxanthone L (2), were isolated from Calophyllum pseudomole stem barks. The structures of both xanthones were determined based on UV, HRESI-MS, 1D, and 2D NMR spectral data. Compounds 1-2 showed xanthine oxidase inhibitory activity with an IC50 of 15.05 and 17.7 μM, respectively, and were categorized as potent.