Role of IFN-γ, TNF-α, IL-6 and C-Reactive Protein in Newly Diagnosed Iraqi Corona Patients

Abstract

The exceptional conditions sweeping the world due to the Corona virus epidemic have prompted researchers to race to study each of the symptoms, phenomena and relevant clinical biochemical parameters to provide science and scientists with valuable information to achieve victory over the virus. The aim of this investigation is to study the early inflammatory features caused by the immune system before a cell storm occurs in Iraqi Corona patients. The investigation was conducted at Yarmouk Teaching Hospital, Baghdad, Iraq, during the period from January 2021 until the end of March 2021. Our team obtained five milliliters of venous blood from 50 participants newly diagnosed with the Coronavirus (24 males and 26 females). Their ages ranged between (25-55) years compared to 38 individuals (18 males and 20 females). Corona virus patients had statistically significant higher (P˂0.01) with Low density lipoproteins-cholesterol (LDL-C), urea, C-Reactive Protein (CRP), and (P˂0.001) with D-dimer when they were compared with control group. There was a significant increase in the value of Interleukin-6(IL-6) in people infected with the virus compared to the reviewers whose swab results showed that they were not infected with the virus. For both interferon-ɤ (IFN) and Tumor necrosis factor -α (TNF- α), the data showed a significant decrease in morale of reviewers diagnosed with acute respiratory syndrome (COVID-19) against their non-infected peers. These data indicate that early intervention for IFN antiviral infection could be fundamental in inhibiting fibrosis to improve functional recovery. Any source of cytokine control, such as interferon-ɤ and Tumor necrosis factor -α combined with combination therapies for clinical treatment, will be important in the future for COVID-19 infection.