Fat‐fated microglial dysfunction

Abstract

© 2018 Agency for Science, Technology and Research (A*STAR) Patients with lysosomal storage disorders (LSDs) exhibit activated microglia in the brain, but the mechanisms underlying microglial activation and contribution to disease pathology are unclear. In this issue, Gabandé-Rodríguez et al present intriguing data to suggest a protective function for microglia that is corrupted by sphingolipid lysosomal overload in Niemann-Pick disease type A.