A computational model of ureteral peristalsis and an investigation into ureteral reflux

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Abstract

The aim of this study is to create a computational model of the human ureteral system that accurately replicates the peristaltic movement of the ureter for a variety of physiological and pathological functions. The objectives of this research are met using our in-house fluid-structural dynamics code (CgLes–Y code). A realistic peristaltic motion of the ureter is modelled using a novel piecewise linear force model. The urodynamic responses are investigated under two conditions of a healthy and a depressed contraction force. A ureteral pressure during the contraction shows a very good agreement with corresponding clinical data. The results also show a dependency of the wall shear stresses on the contraction velocity and it confirms the presence of a high shear stress at the proximal part of the ureter. Additionally, it is shown that an inefficient lumen contraction can increase the possibility of a continuous reflux during the propagation of peristalsis.

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Hosseini, G., Ji, C., Xu, D., Rezaienia, M. A., Avital, E., Munjiza, A., … Green, J. S. A. (2018). A computational model of ureteral peristalsis and an investigation into ureteral reflux. Biomedical Engineering Letters, 8(1), 117–125. https://doi.org/10.1007/s13534-017-0053-0

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