Effect of oral fluconazole 1200mg/day on QT interval in African adults with HIV-associated cryptococcal meningitis

Abstract

We assessed the effect of fluconazole 1200 mg/day on the QT interval in cryptococcal meningitis patients. Mean corrected QT (QTc) change from baseline to day 7 was 10.1 ms (IQR: S28 to 46 ms) in the fluconazole treatment group and S12.6 ms (IQR: S39 to 13.5 ms) in those not taking fluconazole (P U 0.04). No significant increase in QTc measurements over 500 ms was observed with fluconazole. Nevertheless, it remains important to correct any electrolyte imbalance and avoid concomitant drugs that may increase QTc.