Nonlinear-optical brain anatomy by harmonic-generation and coherent Raman microscopy on a compact femtosecond laser platform

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Abstract

An extended-cavity Cr:forsterite laser is integrated with a photonic-crystal fiber soliton frequency shifter and a periodically poled lithium niobate spectrum compressor for simultaneous harmonic-generation and coherent Raman brain imaging. Adapting the laser beam focusing geometry to the tissue morphology is shown to enable complementarity enhancement in tissue imaging by second- and third-harmonic generation, as well as coherent Raman scattering, facilitating quantitative image analysis. © 2011 American Institute of Physics.

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Doronina-Amitonova, L. V., Lanin, A. A., Ivashkina, O. I., Zots, M. A., Fedotov, A. B., Anokhin, K. V., & Zheltikov, A. M. (2011). Nonlinear-optical brain anatomy by harmonic-generation and coherent Raman microscopy on a compact femtosecond laser platform. Applied Physics Letters, 99(23). https://doi.org/10.1063/1.3664345

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