Prediction of torsade de pointes from the QT interval: Analysis of a case series of amisulpride overdoses

Abstract

Electrocardiograms (ECGs) from a case series of 86 amisulpride overdose events in 66 patients were reviewed for abnormal QT intervals and torsade de pointes (TdP). Eight patients exhibited TdP. In this investigative case series, the magnitude of prolongation of the QT interval was a stronger predictor of TdP than the mere presence of a prolongation per se. © 2011 american society for Clinical Pharmacology and therapeutics.