Aqueous phase synthesis of bridgehead azaheterocycles in the presence of β-cyclodextrin

Abstract

A simple and expeditious aqueous phase reaction of various α-bromoketones with 2-aminopyridine, 2-aminopyrimidine, 2-aminopyrazine, and their derivatives, and 2-aminobezothiazole in the presence of β-cyclodextrin has been demonstrated to furnish bridgehead azaheterocycles 5a-j, 7a-e, 9a-d, 12a, 12b and benzo[d]imidazo[2,1-b]thiazoles 11a-c respectively, in good to excellent yields. ©ARKAT USA, Inc.