Concentrations of endothelin-1 associated with aging of prehypertension patients in Denpasar and Badung districts, Bali, Indonesia

Abstract

Introduction: Hypertension is a major health problem in the world. Prehypertension increases the risk of developing hypertension. Aging often accompanied with an elevation of blood pressure. Endothelin-1 is a potent vascular vasoconstrictor which its concentration is related to various cardiovascular diseases including hypertension. However, it is still unclear whether aging is related to endothelin-1 activation. Therefore, this study aims to determine the correlation between age and serum endothelin-1 concentration in patients with prehypertension. Methods: This is a community-based and cross-sectional study which was conducted in Denpasar and Badung regencies, Bali-Indonesia. A total of 75 prehypertension patients were involved in the study. Results: Spearman Correlation analysis demonstrated that age was strongly correlated with endhotelin-1 levels in the patients with prehypertension, R = 0.290 (p = 0.012). Age was also positively correlated with systolic blood pressure R = 0.235 (p = 0.042). In contrast, there was no correlation between age with diastolic blood pressure, R = 0.037 (p = 0.750). Conclusion: In conclusion, endothelin-1 concentration were correlated with the age of patients with prehypertension.