Role of the intrarenal renin-angiotensin system in the control of renal function

Abstract

In this review article, we will assess the evidence for the presence and the mechanism of the intrarenal renin-angiotensin system acting as a local hormonal system in the control of renal function. First, we will review the evidence for the presence of a renin-angiotensin system in the kidney. Second, using results of our own and other studies, we will develop the concept that the intrarenal renin-angiotensin system acts as a local hormonal system in the control of renal function. Third, we will discuss experimental observations on the intrarenal effects of angiotensin II. Fourth, we will evaluate the evidence for a direct renal tubular action of angiotensin II. Fifth, we will assess the role of the intrarenal renin-angiotensin system in renal autoregulation. Finally, we will speculate on the function of the intrarenal renin-angiotensin system in the regulation of fluid and electrolyte homeostasis in general.