Impact of Continuous Integration on Software Quality and Productivity

Abstract

MOTIVATION: This article extends our recent research on penalized estimation methods in genome-wide association studies to the realm of rare variants.RESULTS: The new strategy is tested on both simulated and real data. Our findings on breast cancer data replicate previous results and shed light on variant effects within genes.AVAILABILITY: Rare variant discovery by group penalized regression is now implemented in the free program Mendel at http://www.genetics.ucla.edu/software/.