Ribosomal RNA gene transcription mediated by the master genome regulator protein CCCTC-binding factor (CTCF) is negatively regulated by the condensin complex

Abstract

Background: Condensin and CTCF regulate the state of rDNA repeats. Results: Condensin interacts with CTCF and negatively regulates CTCF-mediated rRNA gene transcription. Conclusion: Condensin and CTCF form a complex and play a negative role in regulation of rRNA gene transcription. Significance: Regulation of rRNA gene transcription by condensin and CTCF indicates that chromatin binding protein and the status of the chromosome play important roles in the regulation of rRNA gene transcription. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.