Synthesis of the hexahydronaphthalene moiety of (+)-mevinolin

Abstract

The synthesis of the hexahydronaphthalene moiety (6b) of (+)-mevinolin (1) has been achieved in 10 steps using an intramolecular Diels-Alder reaction of an alkenylallene to set up four of the chiral centers and the diene unit of (6b). © 1983.