The interaction of [Pd(N,N-dimethylaminopro-pylamine)(H 2O)] 2+ with dicarboxylic acids and inosine: Thermodynamic model for carboplatin drug

Abstract

The Pd(DMPA)Cl 2 complex, where DMPA = N,N- dimethylaminoproylamine, was synthesized and characterized. The stoichiometry and stability constants of the complexes formed between various dicarboxylic acids and [Pd(DMPA)(H 2O) 2] 2+ were investigated. The effect of solvent dielectric constant, chloride ion concentration of the medium and temperature on the stability constant of the cyclobutanedicaroxylic acid (CBDCA) complex was investigated. The equilibrium constants for the displacement of coordinated CBDCA by inosine, taken as an example of DNA constituents, were calculated. The results are expected to contribute to the chemistry of antitumour agents. © Versita Sp. z o.o.