Glutathione peroxidase mimics based on conformationally-restricted,peri-like, 4,5-disubstituted fluorene dichalcogenides

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Abstract

Glutathione peroxidase (GPx) regulates cellular peroxide levels through glutathione oxidation. GPx-mimics based on 4,5-disubstituted fluorene diselenides, their oxides, and ditellurides show catalytic activities consistent with conformational restriction about the dichalcogen bond.

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Jagdev, K., Tanini, D., Lownes, J. W., Figliola, C., Male, L., Capperucci, A., & Grainger, R. S. (2021). Glutathione peroxidase mimics based on conformationally-restricted,peri-like, 4,5-disubstituted fluorene dichalcogenides. Organic and Biomolecular Chemistry, 19(48), 10565–10569. https://doi.org/10.1039/d1ob02153b

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