Abstract
The synthesis and MMP inhibitory activity of a series of tetrahydroisoquinoline based sulfonamide hydroxamates are described. In nine MMPs tested, most of the compounds display potent inhibition activity except for MMP-7. Some subtle isozyme selectivity is observed by varying the substituents at the 6- and 7-positions and aromatic ring of arylsulfonyl groups. © 2003 Elsevier Ltd. All rights reserved.
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Ma, D., Wu, W., Yang, G., Li, J., Li, J., & Ye, Q. (2004). Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors. Bioorganic and Medicinal Chemistry Letters, 14(1), 47–50. https://doi.org/10.1016/j.bmcl.2003.10.026
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