MECHANISM OF ACTION OF ORAL ANTI‐DIABETIC DRUGS

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Abstract

The fall in blood sugar with carbutamide (BZ55) 24 hr. after the maintenance dose of insulin (28.1% ± 2.9 s.e.) in rabbits made severely diabetic with alloxan was significantly different from the change in the blood sugar with the same drug given 72 hr. (6.8% ± 2.0) or distilled water given 24 hr. (7.7% ± 1.3) respectively after the last dose of insulin. It is postulated that the drug acts by liberating bound insulin in the plasma. 1959 British Pharmacological Society

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AIMAN, R., & CHAUDHARY, N. (1959). MECHANISM OF ACTION OF ORAL ANTI‐DIABETIC DRUGS. British Journal of Pharmacology and Chemotherapy, 14(3), 377–379. https://doi.org/10.1111/j.1476-5381.1959.tb00261.x

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