Synthesis and antimicrobial activities of Diphenyl(Arylamino)(1-Phenyl-3- (Pyridin-2-Yl)-1 H -Pyrazol-4-Yl)Methylphosphonates

Abstract

A series of novel diphenyl(arylamino)(1-phenyl-3-(pyridin-2-yl)-1H-pyrazol- 4-yl)methylphosphonates have been synthesized in high yields. They were screened for their antibacterial activities against Escherichia coli (NCIM2065) as a Gram-negative bacterium, Bacillus subtilis (PC1219) and Staphylococcus aureus (ATCC25292) as Gram-positive bacteria, and Schccaromycies cerevisiae as a fungus. The minimum inhibitory concentrations (MICs) of the synthetic compounds showed moderate antibacterial and antifungal activities at low concentrations (10-1000g/mL). Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. © 2012 Copyright Taylor and Francis Group, LLC.