Emulsion preparation using β-cyclodextrin and its derivatives acting as an emulsifier

Abstract

The preparation and formation mechanism of n-hexadecane/water emulsions using natural β-cyclodextrin (β-CD) and chemically modified β-CDs (triacylated β-cyclodextrins) as an emulsifier were investigated. The stable water/oil (W/O) emulsion was formed using tripropanoyl-β-CD (TP-β-CD). From observation using the contact angle (θow) of precipitates derived from CD, it was clarified that oil/water (O/W) emulsion at θow<90° and (W/O) emulsion at θ ow>90° are formed when the composition of each oil and water was mixed with natural β-CD or triacylated β-CDs. © 2008 Pharmaceutical Society of Japan.