Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst

Abstract

Background: Innate immune cell oxidative burst is needed to combat pathogens. Results: Loss of Shp2 phosphatase reduces, whereas increased Shp2 phosphatase function enhances, ROS production. Conclusion: The Shp2 phosphatase domain is specifically required for optimal oxidative burst in macrophages. Significance: Humans bearing aberrancies of Shp2 phosphatase or of Shp2-containing signaling pathways may be prone to impaired or excessive ROS production.