Diastereoselective synthesis of trifluoromethylated 1,3-dioxanes by intramolecular oxa-Michael reaction

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Abstract

A highly diastereoselective synthesis of trifluoromethylated 1,3-dioxanes is described. The reaction proceeds by an addition/oxa-Michael sequence and works efficiently under mild reaction conditions, with a good substrate scope and acceptable to good yields.

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Becerra-Figueroa, L., Brun, E., Mathieson, M., Farrugia, L. J., Wilson, C., Prunet, J., & Gamba-Sánchez, D. (2017). Diastereoselective synthesis of trifluoromethylated 1,3-dioxanes by intramolecular oxa-Michael reaction. Organic and Biomolecular Chemistry, 15(2), 301–305. https://doi.org/10.1039/C6OB02333A

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