University of Toronto case-control study of multiple chemical sensitivity-3: Intra-erythrocytic mineral levels

Abstract

Background: Multiple chemical sensitivity (MCS) has an estimated American prevalence of 15%, and no consistently abnormal laboratory tests are available to assist in its diagnosis. Some physicians treating MCS patients have observed changes in intra-erythrocytic minerals (IEMs). As co-factors, minerals could influence detoxication of xenobiotics. Aim: To test whether IEM differed comparing MCS cases with controls. Methods: A total of 408 women meeting validated inclusion and exclusion criteria for MCS participated in this case-control study. Results: No statistically significant differences were observed. However, for copper, chromium, magnesium, molybdenum, sulphur and zinc, mean detectable levels were all lower in cases. No dose-response relationships were found. Conclusion: IEM measurements do not appear to provide useful diagnostic markers for MCS. © 2007 Oxford University Press.