The effect of anti pollutant gel from sansevieria trifasciata on malondialdehyde level and histopathology of Rats' Liver and Lungs induced by Cigarette, Coal, and mosquito smoke

Abstract

Gas pollutants that accumulate in the room with restricted air circulation may cause respiratory system disorders. A pregnane glycoside compound from Sansevieria can reduce the pollutants. This study aims at producing gels from Sansevieria extract to neutralize indoor gas pollutants. Sansevieria extract is produced by maceration process with composition 8g simplicia and 100mL ethanol 96%. The extract was processed into the gel with 20% concentration. The gel was applied to rats (Rattus norvegicus) Wistar strain induced by cigarette, coal, and mosquito smoke with positive control and treatment groups. After 8 days, Gross examination and histopathology of lungs and liver were observed quantitatively. MDA levels were measured with TBARS method. Data were analyzed by independent sample T-test and Mann-Whitney test with p value considered significant if <0.05. Gross examination of lungs showed a significant difference between treatment and control group that was induced by coal smoke (p=0.031), and mosquito smoke (p=0.006) and liver's gross of cigarette smoke (p=0.040). Histopathology of lungs showed a significant difference in mosquito smoke (p=0.032) and no significant difference in histopathology of the liver. MDA levels showed significant difference in coal smoke (p=0.020) and mosquito smoke (p=0.000). In conclusion, anti pollutant gel reduces MDA levels and damage of the lungs induced by pollutants.