Role of the Chalcogen (S, Se, Te) in the Oxidation Mechanism of the Glutathione Peroxidase Active Site

Abstract

The front cover artwork is provided by the groups of Prof. Dr. F. Matthias Bickelhaupt (VU Amsterdam, The Netherlands) and Prof. Dr. Laura Orian (Università degli Studi di Padova, Italy). The GPx active sites resemble lightning bolts during a thunderstorm (S and Te mutants), and during a clear night for Sec-GPx, associating its much higher anti-oxidant power to the tremendously powerful positive lightning bolts. Read the full text of the article at 10.1002/cphc.201700743.