Electrospinning of Heparin Encapsulated P(LLA-CL) Core/Shell Nanofibers

Abstract

See, stats, and : https : / / www . researchgate . net / publication / 225030766 Electrospinning P (LLA- CL) Core / Shell Article DOI : 10. 5101 / nbe . v2i1 . p56 - 60 CITATIONS 11 READS 87 3 , including : Feng Chinese 108 , 030 SEE Peng National 120 , 064 SEE All . The . All - text and , letting . Abstract Coaxial electrospinning was developed for simultaneously electrospinning two different polymer solutions into core / shell nanofibers , or encapsulated bioactive molecular and drugs into polymer nanofibers for controlled release . In this study , heparin encapsulated poly (L - lactic acid - co - ε - caprolactone) [ P (LLA - CL) ] core / shell nanofibers were fabricated in water / 2 , 2 , 2 - Trifluoroethanol mixed solvent through coaxial electrospinning . TEM images clearly proved the core / shell structure of nanofibers when the proportion of feeding rates of inner and outer solutions was at 1 : 3 . The morphology of these nanofibers were investigated and discussed from SEM micrographs , and the diameters showed a normal distribution . Furthermore , the fabrics of heparin encapsulated P (LLA - CL) core / shell nanofibers showed a strong inhibit ability on proliferation of fibroblast in cell viability test in vitro . Citation : F . Chen et al , Electrospinning of Heparin Encapsulated P (LLA - CL) Core / Shell Nanofibers , Nano Biomed Eng . 2010 , 2 (1) , 56 - 60 . DOI : 10 . 5101 / nbe . v2i1 . p56 - 60 .